The Abandoned Side of the Internet: Hijacking Internet Resources When Domain Names Expire

The vulnerability of the Internet has been demonstrated by prominent IP prefix hijacking events. Major outages such as the China Telecom incident in 2010 stimulate speculations about malicious intentions behind such anomalies. Surprisingly, almost all discussions in the current literature assume that hijacking incidents are enabled by the lack of security mechanisms in the inter-domain routing protocol BGP. In this paper, we discuss an attacker model that accounts for the hijacking of network ownership information stored in Regional Internet Registry (RIR) databases. We show that such threats emerge from abandoned Internet resources (e.g., IP address blocks, AS numbers). When DNS names expire, attackers gain the opportunity to take resource ownership by re-registering domain names that are referenced by corresponding RIR database objects. We argue that this kind of attack is more attractive than conventional hijacking, since the attacker can act in full anonymity on behalf of a victim. Despite corresponding incidents have been observed in the past, current detection techniques are not qualified to deal with these attacks. We show that they are feasible with very little effort, and analyze the risk potential of abandoned Internet resources for the European service region: our findings reveal that currently 73 /24 IP prefixes and 7 ASes are vulnerable to be stealthily abused. We discuss countermeasures and outline research directions towards preventive solutions.Comment: Final version for TMA 201

Assessing learning and memory in pigs

In recent years, there has been a surge of interest in (mini) pigs (Sus scrofa) as species for cognitive research. A major reason for this is their physiological and anatomical similarity with humans. For example, pigs possess a well-developed, large brain. Assessment of the learning and memory functions of pigs is not only relevant to human research but also to animal welfare, given the nature of current farming practices and the demands they make on animal health and behavior. In this article, we review studies of pig cognition, focusing on the underlying processes and mechanisms, with a view to identifying. Our goal is to aid the selection of appropriate cognitive tasks for research into pig cognition. To this end, we formulated several basic criteria for pig cognition tests and then applied these criteria and knowledge about pig-specific sensorimotor abilities and behavior to evaluate the merits, drawbacks, and limitations of the different types of tests used to date. While behavioral studies using (mini) pigs have shown that this species can perform learning and memory tasks, and much has been learned about pig cognition, results have not been replicated or proven replicable because of the lack of validated, translational behavioral paradigms that are specially suited to tap specific aspects of pig cognition. We identified several promising types of tasks for use in studies of pig cognition, such as versatile spatial free-choice type tasks that allow the simultaneous measurement of several behavioral domains. The use of appropriate tasks will facilitate the collection of reliable and valid data on pig cognition

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

The Transitional Justice and Foreign Policy Nexus: The Inefficient Causation of State Ontological Security-Seeking

How does an approach towards transitional justice produce preconditions for a country’s international action, enabling certain policies and practices in the immediate neighborhood and international society at large? This article unpacks ontological security-seeking as a generic social mechanism in international politics which allows to productively conceptualize the connection between a state’s transitional justice and foreign policies. Going beyond the dichotomy of transitional justice compliance and non-compliance by gauging the role of states’ subjective sense of self in driving their behavior, I develop an analytical framework to explain how state ontological security-seeking relates to major transitions and consequent state identity disjuncture, the ensuing politics of truth and justice-seeking, and its international resonance in framing and executing particular foreign policies. I offer a typology of the international consequences of states’ transitional justice politics, distinguishing between reflective and mnemonical security-oriented approaches, spawning cooperative and conflictual foreign policy behavior, respectively. The empirical purchase of the purported nexus is illustrated with the example of post-Soviet Russia’s limited politics of accountability towards the repressions of its antecedent regime and its increasingly self-assertive and confrontational stance in contemporary international politics

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

The Universal Future of the Risen Christ - A Study on the Development of Jürgen Moltmann’s Eschatology

This thesis is a study on the development of the German theologian Jürgen Moltmann’s understanding of eschatology. Eschatology is often described as ‘the doctrine of last things’ but Moltmann considers this to be a mistaken point of view, rather he claims that eschatology is the ‘doctrine of the Christian hope’. This hope is according to Moltmann based on the belief that Christ was raised from the dead and that his resurrection unveils the universal future of the whole cosmos. This is the foundation in Moltmann’s chain of logic and throughout this thesis I will demonstrate how he develops this notion in relation to his belief in a God who suffers with the victims in this world

Certificate Transparency in Theory and Practice

Certificate Transparency provides auditability to the widely used X.509 Public Key Infrastructure (PKIX) authentication in Transport Layer Security (TLS) protocol. Transparency logs issue signed promises of inclusions to be used together with certificates for authentication of TLS servers. Google Chrome enforces the use of Certificate Transparency for validation of Extended Validation (EV) certificates. This thesis proposes a methodology for asserting correct operation and presents a survey of active Logs. An experimental Monitor has been implemented as part of the thesis. Varying Log usage patterns and metadata about Log operation are presented, and Logs are categorized based on characteristics and usage. A case of mis-issuance by Symantec is presented to show the effectiveness of Certificate Transparency